منابع مشابه
Biosynthesis of chloramphenicol. IV. Incorporation of carbon 14-labled precursors.
Gottlieb, David (University of Illinois, Urbana), H. E. Carter, P. W. Robbins, and R. W. Burg. Biosynthesis of chloramphenicol. IV. Incorporation of carbon(14)-labeled precursors. J. Bacteriol. 84:888-895. 1962.-Metabolism of dl-phenylalanine stimulated antibiotic synthesis by Streptomyces venezuelae, and resulted in the fixation of carbons 1 and 2 into the carbonyl group of chloramphenicol. It...
متن کاملCmlI is an N-oxygenase in the biosynthesis of chloramphenicol.
The N-oxygenation of an amine group is one of the steps in the biosynthesis of the antibiotic chloramphenicol. The non-heme di-iron enzyme CmlI was identified as the enzyme catalyzing this reaction through bioinformatics studies and reconstitution of enzymatic activity. In vitro reconstitution was achieved using phenazine methosulfate and NADH as electron mediators, while in vivo activity was d...
متن کاملNew Insights into Chloramphenicol Biosynthesis in Streptomyces venezuelae ATCC 10712
Comparative genome analysis revealed seven uncharacterized genes, sven0909 to sven0915, adjacent to the previously identified chloramphenicol biosynthetic gene cluster (sven0916-sven0928) of Streptomyces venezuelae strain ATCC 10712 that was absent in a closely related Streptomyces strain that does not produce chloramphenicol. Transcriptional analysis suggested that three of these genes might b...
متن کاملChloramphenicol binding site with analogues of chloramphenicol and puromycin.
The effect of a series of puromycin analogues and aminoacyl chloramphenicol derivatives on poly(U,C)-directed polyphenylalanine synthesis in an Escherichia coli cell-free system was examined. A comparison between the structures and activities of the puromycin and chloramphenicol analogues was made to examine the proposal that ribosomal binding sites for both antibiotics overlap. Our results sug...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1962
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.84.5.888-895.1962